Ghana is without goalkeeper Jojo Wollacott after he suffered a finger injury during a club game before the World cup tournament.
The Black Stars first-choice goalkeeper, Wollacott, was injured in the warm-up for a League One match at Burton on Saturday, and has been left out of the squad.
Ghana are the lowest-ranked team at the tournament and will face Portugal, South Korea and Uruguay in Group H without the 26 year old Charlton Athletic goalkeeper.
Wollacott had started all three of Ghana’s games at the Africa Cup of Nations earlier this year, and both legs of the World Cup play-off against Nigeria in March.
With Richard Ofori also injured, Addo will now have to choose between Eupen keeper Abdul Manaf Nurudeen, St Gallen’s Lawrence Ati-Zigi and Danlad Ibrahim of domestic club Asante Kotoko.
Addo has also left out Crystal Palace midfielder Jeffrey Schlupp and Cremonese forward Felix Afena-Gyan, while midfielders Mubarak Wakaso, Joseph Paintsil and Idrissu Baba are the other significant names omitted from the squad.
Uncapped forward Kamal Sowah makes the squad after impressing for Club Bruges as the Belgian club reached the last 16 of the Champions League.
Ghana face Switzerland in a friendly in Abu Dhabi on Thursday, and begin their Group H campaign against Portugal on 24 November.
Ghana reached the quarter-finals in the 2010 World Cup, when beaten by Uruguay on penalties in a controversial tie, and suffered an early exit in 2014 prior to missing out altogether for the 2018 finals in Russia.